Nolvadex was discovered in the late 1980s as a drug used to treat breast cancer. The compound, which is chemically identical to tamoxifen, is also used in the treatment of, and to reduce the risk of estrogen receptor-positive breast cancer.
Mechanism of Action
Nolvadex inhibits estrogen-sensitive breast cancer by binding to estrogen receptors at the protein-ensed and carbohydrate-OSE domains. Nolvadex, in turn, prevents the binding of estrogens to estrogen receptors. Nolvadex is also in the treatment of.
Clinical Pharmacology
Nolvadex is a synthetic estrogen agonist. It binds to estrogen receptors in breast cancer cells and inhibits their growth.
Pharmacokinetics
Nolvadex is a single dose, fast acting drug. Its peak plasma concentration is achieved within approximately 1 hour.
Pharmacokinetics in Special Populations
The bioavailability of Nolvadex in the general population ranges between 63% and 77%.
Efficacy in Breast Cancer Patients
In clinical trials, Nolvadex significantly reduced the risk of distant recurrence in patients with early-stage disease. Nolvadex is not approved for use in women as it is known to have a small but significant risk of.
Controlled Trials
Nolvadex has not been studied in controlled trials. Nolvadex is not approved for use in women as it is known to have a small but significant risk of breast cancer.
Controlled Trials in Gynecology
In a controlled trial, Nolvadex was shown to reduce the risk of endometrial hyperplasia (increased risk of endometrial hyperplasia compared to tamoxifen) in premenopausal women. The data did not show any significant differences in the risk of endometrial hyperplasia between tamoxifen and nolvadex. However, the data from the trials did not demonstrate any benefit.
Safety in Pediatric Patients
Nolvadex is not approved for use in pediatric patients. The safety profile of Nolvadex in patients with breast cancer has not been established.
Its peak plasma concentration is approximately 1 hour after administration.
Pharmacokinetics in Special Populations in hepatic coma
The serum concentration is approximately 50% of the peak concentration.
Pharmacokinetics in Elderly Patients
A single dose, fast acting drug. The serum concentration is approximately 15% of the peak plasma concentration.
Pharmacokinetics in Renal Impairment
A single dose, slow acting drug. The serum concentration is approximately 5% of the peak concentration.
The serum concentration is approximately 2% of the peak plasma concentration.
Pharmacokinetics in Pediatric Patients
The serum half-life is approximately 3 hours. The serum half-life is approximately 15 to 20 hours.
Pharmacokinetics in Pediatric Patients with Renal Impairment
The serum half-life is approximately 3 to 5 hours.
The serum half-life is approximately 2 to 3 hours.
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NOLVADEX contains Tamoxifen which belongs to the group of medicines called Anti-estrogen agents. It is used for breast cancer. This medicine is also used for reproductive health in women caused by a failure to produce and release eggs. Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer.
Along with this management, your doctor might ask you to make certain lifestyle changes such as eating a healthy diet, healthy sleep habits and managing your weight. Prior to the management, your doctor may want you to take certain breast examinations to understand your existing condition. NOLVADEX is not recommended for use in patients with a history of blood clots (including family).
NOLVADEX should be used with caution in patients with a history of hereditary angioedema. NOLVADEX is not recommended for use in pregnant women. Inform your doctor before taking NOLVADEX if you are breastfeeding. NOLVADEX is not recommended for use in children. The most common side effects of taking NOLVADEX are nausea, fluid retention, skin rash, hot flushes, tiredness and anemia. Consult your doctor if any of the above side effects worsen or persist for a long time.
As taking NOLVADEX may cause an increase in blood pressure, symptoms such as headaches, nausea, fluid retention, muscle weakness, irregular heartbeat and others could be dangerous. Therefore, consult your doctor if any of the above side effects trouble you or cause any serious side effects. Before taking NOLVADEX, you should know if you are sexually active. Furthermore, you should also read the controlled literature which allows for safe and suitable management of vaginal atrophy. NOLVADEX. Associated with other side effects. Consult your doctor before taking this medicine if you are pregnant or breastfeeding. The most common side effects of taking NOLVEX are nausea, fluid retention, skin rash, hot flushes, tiredness and anemia. Consult your doctor if your doctor cannot, or not are an appropriate treatment for your condition. Consult your doctor if you are breastfeeding. NOLVADEX is not recommended for use in treating atrophy of the female genital organs in women with cancer.You should know your menarpless menarpless status before taking NOLVEX. Consult your doctor if you are pregnant or breastfeeding. Consult your doctor if you are breast-feeding. Consult your doctor if you are taking any other medicines. NOLVADEX is not recommended for use in treating breast cancer. In case of accidental overdose, get medical help.What you need to know about its uses. Before taking it, talk to your doctor if you are taking any oral medication, including those used for vaginal atrophy (including Trimix, Unimatital and Intrauterine ).You should know that NOLVADEX. However, not all of the side effects caused by NOLVADEX. You should not take NOLVADEX if you are taking nitrates (e.g. nitroglycerin for angina) or if you have had a stroke or heart attack. Associated with your breast cancer. Associated with your cancer. Consult your doctor if you are taking any medication for high blood pressure, including certain medicines used to treat high blood pressure. Associated with your blood pressure lowering medications (e.g. losartan, valsartin) or any alpha-blockers (e.g. Propranolol). Talk to your doctor if you are taking any other medications.NOLVADEX contains Tamoxifen which belongs to the group of medicines called Anti-estrogen agents. It is used for breast cancer. This medicine is also used for reproductive health in women caused by a failure to produce and release eggs. Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer.
Along with this management, your doctor might ask you to make certain lifestyle changes such as eating a healthy diet, healthy sleep habits and managing your weight. Prior to the management, your doctor may want you to take certain breast examinations to understand your existing condition. NOLVADEX is not recommended for use in patients with a history of blood clots (including family).
NOLVADEX should be used with caution in patients with a history of hereditary angioedema. NOLVADEX is not recommended for use in pregnant women. Inform your doctor before taking NOLVADEX if you are breastfeeding. NOLVADEX is not recommended for use in children. The most common side effects of taking NOLVADEX are nausea, fluid retention, skin rash, hot flushes, tiredness and anemia. Consult your doctor if any of the above side effects worsen or persist for a long time.
How should I take NOLVADEX?The usual recommended dose of NOLVADEX is 1 gram every 8 hours as needed. You may take this dose with or without food. However, the following dose should not be taken without doctor's advice:
NOLVADEX is not recommended for use if you are allergic to Tamoxifen or any of the other ingredients of this medicine. Before taking NOLVADEX, your doctor should consider your medical history: whether you or your doctor will ever have any problems with your breast lining (stools or urgent treatment of serious medical conditions) or any other medical conditions of your heart. Your doctor might recommend breast conservation or a reduced-calorie diet.
The maximum recommended dosing frequency for NOLVADEX is once per day. If you are taking oral tablet then take it as directed. If you are taking herbal medicine then consult your doctor before taking NOLVADEX. NOLVADEX should be taken with a low-fat diet (low in fat and high in fat) and regular exercise.
Keep in mind that NOLVADEX is a hormone antagonist which works by blocking the action of a hormone called estrogen. NOLVADEX can control the breast cancers in breast cancer patients. Refer to for more details.
Sophie and The NOLVADEXEXEXEWESTYou must tell your doctor about any existing medical conditions of your heart before taking NOLVADEX.
NOLVADEX is a medicine used for breast cancer. It belongs to the group of medicines called Anti-estrogen agents.
Sold and Supplied by Healthylife Pharmacy
This product is a Prescription Only Medicine (S4) and is sold by Healthylife Pharmacy, an independently owned and operated pharmacy business. This prescription product requires a valid Australian script.
Medicare CardNo MedicareConcession
$21.95
Healthylife provides general product information such as nutritional information, country of origin and product packaging for your convenience. This information is intended as a guide only, including because products change from time to time. Please read product labels before consuming. For therapeutic goods, always read the label and follow the directions for use on pack. If you require specific information to assist with your purchasing decision, we recommend that you contact the manufacturer via the contact details on the packaging or email us at [email protected]. Product ratings and reviews are taken from various sources including Bazaarvoice. Healthylife does not represent or warrant the accuracy of any statements, claims or opinions made in product ratings and reviews.
Protein(s)for YouDEXICIDE 20 is a combination of an anti-estrogen and an anti-estrogenic agent. Tamoxifen is a synthetic estrogen linked to the production of a bodybuilding hormone that helps to stimulate the growth of pre-menopausal female muscle cells. Tamoxifen is a selective estrogen receptor modulator (SERM) that works by blocking the effects of estrogen on the receptor site in target tissues, thereby blocking the effects of testosterone on these tissues. DEXICIDE 20 is also an oral anti-estrogen and anti-estrogenic agent.
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